Skip to main content
. 2011 Jun 20;6(6):e21312. doi: 10.1371/journal.pone.0021312

Figure 3. FTY720 does not alter infarct volume in alternative experimental protocols.

Figure 3

(A) Representative images of brain sections stained by the silver-staining technique from coagulation-MCAO and transient 60 min filament-MCAO as used for determination of infarct volumes. (B) Brain ischemia was induced by 60 min reversible MCAO and infarct volumes were determined at 24 h after ischemia in animals receiving daily oral administration of FTY720 or PBS starting 48 h before stroke induction (n = 12, p = 0.42, 3 individual experiments). (C, D) FTY720 or PBS were administered by daily i.p. injection starting 48 h berfore MCAO. (C) MCAO was induced by transcranial permanent coagulation and infarct columes determined at 7d after MCAO (n = 10, p = 0.36, 2 individual experiments). (D) MCAO was induced by transient 60 min filament-occlusion of the MCA and infarct volume measured at 24 h after MCAO (n = 9, p = 0.86, 2 individual experiments).