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. 2011 Jun 20;6(6):e21077. doi: 10.1371/journal.pone.0021077

Figure 4. Effect of GYY4137 on tumor growth in vivo.

Figure 4

Changes in volume of established tumors in, (A) HL-60 xenograft mice (B) MV4–11 xenograft mice treated daily with either GYY4137 (100, 200 and 300 mg/kg, i.p.) or vehicle control. Treatment with GYY4137 significantly reduced the tumor volume in both animal models, in a dose-dependent manner. Results show changes of tumor volume in mean ± s.e. mean (n = 4–6, # P<0.05; * P<0.01).