Phenotype of 10-day-old Ryr2ADA/ADA/CNA-β−/− mice. A: survival of Ryr2ADA/ADA mice. Mean survival ± SE in days for Ryr2ADA/ADA mice with CNA-β+/+ (12.7 ± 0.9, n = 10; solid line), CNA-β+/− (15.9 ± 1.1, n = 16; dashes), and CNA-β−/− (25.4 ± 4.6, P < 0.01 compared with CNA-β+/+, n = 8; dots). B: heart weights of 4 genotypes of 10-day-old mice. C: heart-to-body weight ratios of 4 genotypes of 10-day-old mice. B and C: data are means ± SE of 15–26 mice. *P < 0.01 compared with Ryr2+/+/CNA-β+/+ mice (WT); #P < 0.01 compared with Ryr2ADA/ADA/CNA-β+/+.