Table 3.

Calcium handling by membrane fractions isolated from 10-day-old hearts of mice double targeted for RyR2^ADA and CNA-β

Genotype	Bmax of [3H]ryanodine Binding, pmol/mg protein	45Ca2+ Uptake Rate, nmol·mg protein−1·min−1
Ryr2+/+
CNA-β+/+ (WT)	0.35 ± 0.04	1.75 ± 0.19
CNA-β−/−	0.29 ± 0.05	1.64 ± 0.27
Ryr2ADA/ADA
CNA-β+/+	0.15 ± 0.02*	1.48 ± 0.22
CNA-β−/−	0.12 ± 0.01*	1.38 ± 0.18

Values are means ± SE of 5–7 experiments.

^*P < 0.05 compared with Ryr2^+/+/ CNA-β^+/+.