Table 1.

Animal and vessel characteristics

	Young			Old
	Intact	OVX	OVE	Intact	OVX	OVE
n	34	21	23	37	18	31
Animal characteristics
Body wt, g	196 ± 4	249 ± 4†	215 ± 3†‡	300 ± 4*	310 ± 6	274 ± 4†‡
Heart wt, mg	538 ± 11	623 ± 14†	653 ± 13†	766 ± 9*	780 ± 17	794 ± 21
HW/BW	2.76 ± 0.07	2.50 ± 0.04†	3.04 ± 0.05†‡	2.56 ± 0.04*	2.45 ± 0.05	2.96 ± 0.06†‡
Uterine wt, mg	551 ± 32	97 ± 7†	253 ± 18†‡	564 ± 32	279 ± 25†	725 ± 52†‡
UW/BW	2.73 ± 0.17	0.40 ± 0.03†	1.18 ± 0.08†‡	1.91 ± 0.13*	0.90 ± 0.09†	2.67 ± 0.20†‡
Vessel characteristics
Maximal diameter, μm	123 ± 4	123 ± 5	124 ± 6	124 ± 4	119 ± 5	131 ± 5
Tone, %
Baseline	25 ± 1	24 ± 1	25 ± 1	27 ± 1	29 ± 2	29 ± 2
Posttempol	35 ± 3#	22 ± 1	29 ± 3	37 ± 3#	35 ± 5	33 ± 3
Postcatalase	36 ± 3#	24 ± 1	27 ± 2	35 ± 3#	32 ± 4	36 ± 4
Post-DETC	21 ± 1	21 ± 1	23 ± 2	21 ± 1	22 ± 1	21 ± 1

Data are presented as means ± SE;

n, no. of mice. OVX, ovariectomized; OVE, OVX + estrogen treated; HW/BW, heart weight-to-body weight ratio; UW/BW, urine weight-to-body weight ratio; DETC, diethyldithiocarbamate.

P < 0.05 vs. young intact (*), vs. age-matched intact (†), vs. age-matched OVX (‡), and vs. baseline (#).