Table 1.
Young |
Old |
|||||
---|---|---|---|---|---|---|
Intact | OVX | OVE | Intact | OVX | OVE | |
n | 34 | 21 | 23 | 37 | 18 | 31 |
Animal characteristics | ||||||
Body wt, g | 196 ± 4 | 249 ± 4† | 215 ± 3†‡ | 300 ± 4* | 310 ± 6 | 274 ± 4†‡ |
Heart wt, mg | 538 ± 11 | 623 ± 14† | 653 ± 13† | 766 ± 9* | 780 ± 17 | 794 ± 21 |
HW/BW | 2.76 ± 0.07 | 2.50 ± 0.04† | 3.04 ± 0.05†‡ | 2.56 ± 0.04* | 2.45 ± 0.05 | 2.96 ± 0.06†‡ |
Uterine wt, mg | 551 ± 32 | 97 ± 7† | 253 ± 18†‡ | 564 ± 32 | 279 ± 25† | 725 ± 52†‡ |
UW/BW | 2.73 ± 0.17 | 0.40 ± 0.03† | 1.18 ± 0.08†‡ | 1.91 ± 0.13* | 0.90 ± 0.09† | 2.67 ± 0.20†‡ |
Vessel characteristics | ||||||
Maximal diameter, μm | 123 ± 4 | 123 ± 5 | 124 ± 6 | 124 ± 4 | 119 ± 5 | 131 ± 5 |
Tone, % | ||||||
Baseline | 25 ± 1 | 24 ± 1 | 25 ± 1 | 27 ± 1 | 29 ± 2 | 29 ± 2 |
Posttempol | 35 ± 3# | 22 ± 1 | 29 ± 3 | 37 ± 3# | 35 ± 5 | 33 ± 3 |
Postcatalase | 36 ± 3# | 24 ± 1 | 27 ± 2 | 35 ± 3# | 32 ± 4 | 36 ± 4 |
Post-DETC | 21 ± 1 | 21 ± 1 | 23 ± 2 | 21 ± 1 | 22 ± 1 | 21 ± 1 |
Data are presented as means ± SE;
n, no. of mice. OVX, ovariectomized; OVE, OVX + estrogen treated; HW/BW, heart weight-to-body weight ratio; UW/BW, urine weight-to-body weight ratio; DETC, diethyldithiocarbamate.
P < 0.05 vs. young intact (*), vs. age-matched intact (†), vs. age-matched OVX (‡), and vs. baseline (#).