Table 3.

Transcriptional responses of liver from WD- vs. KD-fed mice

	WD	KD
Central metabolic regulators
Fgf21	17.2 ± 7.9a	25.0 ± 4.7b
Ppara	1.2 ± 0.4	0.8 ± 0.2
Ppard	4.8 ± 3.6	1.6 ± 0.4
Pparg	1.9 ± 0.2a	2.5 ± 0.2b
Pparg1	1.2 ± 0.0	3.3 ± 0.3c,f
Pparg2	4.4 ± 0.5b	1.3 ± 0.4e
Ppargc1a	1.5 ± 0.7	0.8 ± 0.2
Ppargc1b	0.8 ± 0.0	0.5 ± 0.1b,e
De novo lipogenesis
Srebf1	2.9 ± 0.5a	0.3 ± 0.1a,d
Fasn	4.7 ± 1.3a	0.2 ± 0.1a,d
Acaca	3.0 ± 0.6b	0.6 ± 0.2e
G6pdx	6.3 ± 1.0b	1.5 ± 0.1a,e
Scd1	7.3 ± 0.3c	0.5 ± 0.1c,f
Gck	2.9 ± 0.3b	0.5 ± 0.1a,e
Fatty acid oxidation/ketogenesis
Slc27a1	0.9 ± 0.1	3.4 ± 0.6b,f
Cd36	3.1 ± 0.3b	5.1 ± 0.5c,d
Acsl1	1.3 ± 0.0	1.9 ± 0.2a,d
Pdk4	6.4 ± 1.1c	6.9 ± 0.6c
Cpt1a	1.8 ± 0.2a	1.3 ± 0.2
Acadm	1.2 ± 0.0	2.0 ± 0.3a,d
Hmgcs2	1.5 ± 0.0b	2.4 ± 0.2b,e
Gluconeogenesis
G6pc	1.1 ± 0.1	1.1 ± 0.1
Pck1	1.1 ± 0.1	1.1 ± 0.1
Inflammation/Fibrosis
Col1a2	1.5 ± 0.4	2.2 ± 0.6
Il6	0.9 ± 0.3	1.1 ± 0.2
Il1b	1.4 ± 0.1	0.9 ± 0.2
Tnf	1.7 ± 0.8	2.4 ± 0.6
Emr1	1.5 ± 0.3	1.7 ± 0.2
Cd68	1.4 ± 0.5	2.4 ± 0.2b
Itgam	1.7 ± 0.5a	2.4 ± 0.3b
Nlrp3	1.1 ± 0.4	1.8 ± 0.2a
Pycard	1.1 ± 0.5	2.1 ± 0.3a
Lipid droplet proteins
Cidea	50.0 ± 14.6b	4.8 ± 1.2a,d
Cideb	0.9 ± 0.2	0.8 ± 0.1
Cidec	7.3 ± 2.0a	9.7 ± 1.3c

Relative abundance (means ±SE), compared with chow, n = 5/group.

^aP < 0.05,

^bP < 0.01, and

^cP < 0.001, respectively, compared with chow.

^dP < 0.05,

^eP < 0.01, and

^fP < 0.001, respectively, compared with WD (by ANOVA with Tukey's post hoc testing).