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. 2011 Mar 17;300(6):G1054–G1064. doi: 10.1152/ajpgi.00055.2011

Fig. 5.

Fig. 5.

Effect of siRNA-induced knock down of claudin-2 on transepithelial flux of varying-sized paracellular markers in occludin (Occ)-depleted Caco-2 monolayers. A and B: claudin-2 depletion did not affect the occludin siRNA-induced increase in flux rate of inulin and 70 kDa dextran (means ± SE, n = 4). *P < 0.0001 vs. control. C: claudin-2 depletion did not affect the occludin siRNA-induced increase in flux rate of mannitol (means ± SE, n = 6). *P < 0.0001 vs. control. D: claudin-2 depletion significantly prevented the occludin siRNA-induced increase in flux rate of urea (means ± SE, n = 6). *P < 0.0035 vs. control. **P < 0.0358 vs. control. #P < 0.0358 vs. occludin siRNA transfection.