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Hypoxia-induced increases in PKC-ε activity are dependent on nitric oxide synthase (NOS) and zinc. A: zinc-induced increases in PKC-ε activity were reversed by TPEN (10 μM, n = 3, P < 0.05). B: hypoxia-induced increases in enzyme activity were reversed by the competitive NOS inhibitor nitro-l-arginine methyl ester (l-NAME) (1 mM) or the zinc-specific chelator, TPEN (10 μM, n = 3, *P < 0.05).
