Table 2.
Extracellular matrix components and processing proteins showing circadian-like oscillations in gene expression
| Symbol | Cluster No. | Gene Name | Gene Function |
|---|---|---|---|
| Adamtsl2 | 1 | ADAMTS-like 2 | Glycoprotein; cell surface and ECM binding |
| Thbs1 | 1 | Thrombospondin 1 | Cell attachment, invasion; cell-ECM interactions |
| Adamts4 | 2 | ADAM metallopeptidase 4 | ECM protease; proteoglycan cleavage |
| Itgb6 | 2 | Integrin-β6 | Receptor: fibronectin and cytotactin |
| Selp | 2 | Selectin P | Receptor for carbohydrates in immune cells |
| Adamts15 | 3 | ADAM metallopeptidase 15 | ECM protease; interacts with integrins |
| Dag1 | 3 | Dystroglycan 1 | ECM receptor; CM-cytoskeleton interactions |
| Eln | 3 | Elastin | Structural component of elastic fibers |
| Emilin1 | 3 | Elastin microfibril interfacer 1 | Formation of elastic fiber |
| Fbn1 | 3 | Fibrillin 1 | Extracellular Ca2+ binding; structural support |
| Itga4 | 3 | Integrin-α4 | Receptor for fibronectin |
| Lox | 3 | Lysyl oxidase | Cross-linking of collagen and elastin |
| Mmp14 | 3 | Matrix metallopeptidase 14 | Breakdown of ECM components |
| Ndst1 | 3 | N-deacetylase/N-sulfotransferase 1 | Biosynthesis of heparan sulfate |
| Spon2 | 3 | Spondin 2 | Pattern recognition for microbes in ECM |
| Xpnpep2 | 3 | X-prolyl aminopeptidase 2 | Hydrolase specific for ECM degradation components |
| Col13a1 | 3 | Collagen, type XIII, α1 | Nonfibrillar collagen; branching morphogenesis of lung |
| Col5a3 | 3 | Collagen, type V, α3 | Interaction with heparan sulfate and thrombospondin |
| Fbln5 | 4 | Fibulin 5 | Interactions with integrins; vascular development |
| Gpc4 | 4 | Glypican 4 | Cell surface proteoglycan; heparan sulfate |
| Tnc | 4 | Tenascin C | Fiber-associated structural protein |
| Adam33 | 5 | ADAM metallopeptidase 33 | ECM protease-cell matrix interactions |
| Adamts1 | 6 | ADAM metallopeptidase 1 | ECM protease-proteoglycan cleavage |
| Itga6 | 6 | Integrin, α6 | Receptor for laminin |
| Mgp | 6 | Matrix Gla protein | Inhibitory morphogen; vascular branching |
| Timp3 | 7 | TIMP metallopeptidase inhibitor 3 | Inhibits MMP |
| Timp4 | 7 | TIMP metallopeptidase inhibitor 4 | Inhibits MMP |
ADAMS, A disintegrin and metalloproteinase with thrombospondin motifs; ECM, extracellular matrix; CM, calmodulin; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase.