Table 5.
Genes associated with lung diseases showing circadian-like oscillations in expression
| Symbol | Cluster No. | Gene Name | Drug Target |
|---|---|---|---|
| Asthma | |||
| *Pdgfra | 1 | Platelet-derived growth factor receptor-α | |
| Eif4e | 1 | Eukaryotic translation initiation factor 4E | |
| *Vasp | 2 | Vasodilator-stimulated phosphoprotein | |
| Selp | 2 | Selectin P | Bimosiamose, rPSGL-1 |
| Cxcl3 | 2 | Chemokine (C-X-C motif) ligand 3 | |
| *Irf1 | 2 | Interferon regulatory factor 1 | |
| Tgm2 | 2 | Transglutaminase 2 | |
| *Adm | 2 | Adrenomedullin | |
| *Rhoa | 2 | Ras homolog gene A | |
| Pdgfrb | 2 | Platelet-derived growth factor receptor-β | |
| Nfil3 | 2 | Nuclear factor, IL-3-regulated | |
| Aqp1 | 2 | Aquaporin 1 | |
| *Itga4 | 3 | Integrin-α4 | |
| Tnfsf10 | 3 | TNF superfamily, member 10 | |
| Emr1 | 3 | EGF-like module containing, 1 | |
| Cxcl12 | 3 | Chemokine (C-X-C motif) ligand 12 | |
| *Adora2a | 3 | Adenosine A2a receptor | Binodenoson |
| Hgf | 3 | Hepatocyte growth factor | Recombinant HGF |
| Pdgfa | 3 | Platelet-derived growth factor-α | |
| *Tnc | 4 | Tenascin C | |
| Ptprd | 4 | Protein tyrosine phosphatase, receptor D | |
| Fyn | 4 | FYN oncogene related to SRC, FGR, YES | |
| Angpt1 | 4 | Angiopoietin 1 | |
| Flt1 | 4 | Fms-related tyrosine kinase 1 | |
| *Marcks | 4 | Myristoylated Ala-rich PKC substrate | Marcks inhibitor peptide |
| *Adam33 | 5 | ADAM metallopeptidase 33 | |
| *Adrb2 | 6 | Adrenergic-β2 receptor | β-Agonists |
| Ppargc1a | 6 | PPARγ coactivator 1α | |
| Cd163 | 7 | CD163 molecule | |
| *Ctgf | 7 | Connective tissue growth factor | |
| *Mrc1 | 7 | Mannose receptor, C1 | |
| *Hspb1 | 8 | Heat shock 27-kDa protein 1 | |
| COPD | |||
| *Pdgfra | 1 | Platelet-derived growth factor receptor α | |
| *Adm | 2 | Adrenomedullin | |
| *Cx3cl1 | 2 | Chemokine (C-X3-C motif) ligand 1 | |
| Mmp14 | 3 | Matrix metallopeptidase 14 | |
| Eln | 3 | Elastin | |
| Fgf1 | 3 | Fibroblast growth factor 1 | |
| Fbn1 | 3 | Fibrillin 1 | |
| *Pde5a | 4 | Phosphodiesterase 5A, cGMP-specific | Sildenafil (Viagra) |
| *Marcks | 4 | Myristoylated Ala-rich PKC substrate | Marcks inhibitor peptide |
| *Adam33 | 5 | ADAM metallopeptidase 33 | |
| *Adrb2 | 6 | Adrenergic β2 receptor | β2-Agonist |
| Tgfbr3 | 6 | Transforming growth factor-β receptor 3 | |
| Hey1 | 6 | Hairy/enhancer-of-split related with YRPW 1 | |
| *Ctgf | 7 | Connective tissue growth factor | |
| *Timp3 | 7 | TIMP metallopeptidase inhibitor 3 | |
| Lung injury | |||
| *Vasp | 2 | Vasodilator-stimulated phosphoprotein | |
| *Ctf1 | 2 | Cardiotrophin 1 | |
| *Itga4 | 3 | Integrin-α4 | |
| Ampd3 | 3 | Adenosine monophosphate deaminase 3 | |
| *Adora2a | 3 | Adenosine A2a receptor | A2a receptor agonist |
| *Tnc | 4 | Tenascin C | |
| *Angpt1 | 4 | Angiopoietin 1 | COMP-Ang1 |
| Mapk1 | 4 | Mitogen-activated protein kinase 1 | PD98059 |
| Mt2A | 6 | Metallothionein 2A | |
| Ddit4 | 6 | DNA damage-inducible transcript 4 | |
| Lifr | 6 | Leukemia inhibitory factor receptor-α | |
| *Rock2 | 6 | Rho-associated, coiled-coil containing PK2 | Y-27632 |
| Map3k2 | 6 | Mitogen-activated protein 3K2 | |
| Aoc3 | 6 | Amine oxidase, copper containing 3 | SZE 5302 |
| *Timp3 | 7 | TIMP metallopeptidase inhibitor 3 | |
| *Hspb1 | 8 | Heat shock 27-kDa protein 1 | |
| Microbial infection | |||
| *Cx3cl1 | 2 | Chemokine (C-X3-C motif) ligand 1 | |
| *Irf1 | 2 | Interferon regulatory factor 1 | |
| Spon2 | 3 | Spondin 2 | |
| Ncf4 | 3 | Neutrophil cytosolic factor 4 | |
| Antxr1/TEM8 | 3 | Anthrax toxin receptor 1 | |
| Colec12 | 4 | Collectin subfamily member 12 | |
| Tbk1 | 4 | TANK-binding kinase 1 | |
| Dhx36 | 4 | DEAH box polypeptide 36 | |
| Ivns1abp | 6 | Influenza virus NS1A binding protein | |
| *Mrc1 | 7 | Mannose receptor, C type 1 | |
| Pulmonary and cystic fibrosis | |||
| *Pdgfra | 1 | Platelet-derived growth factor receptor-α | Imatinib |
| Atf4 | 1 | Activating transcription factor 4 | |
| *Adm | 2 | Adrenomedullin | |
| Grk5 | 2 | G protein-coupled receptor kinase 5 | |
| *Cxcl12 | 3 | Chemokine (C-X-C motif) ligand 12 | Neutralizing antibody |
| Nox4 | 3 | NADPH oxidase 4 | |
| Ednra | 3 | Endothelin receptor type A | |
| LRP6 | 6 | LDLR-related protein 6 | |
| Pulmonary hypertension | |||
| *Thbs1 | 1 | Thrombospondin 1 | |
| *Adm | 2 | Adrenomedullin | |
| *Ctf1 | 2 | Cardiotrophin 1 | Recombinant CTF1 |
| *Pdgfrb | 2 | Platelet-derived growth factor receptor-β | |
| *Rhoa | 2 | Ras homolog gene family, member A | Fasudil |
| Fbln5 | 4 | Fibulin 5 | |
| *Pde5a | 4 | Phosphodiesterase 5A, cGMP-specific | Sildenafil (Viagra) |
| *Tfpi | 4 | Tissue factor pathway inhibitor | |
| Alas1 | 6 | Aminolevulinate-δ synthase 1 | |
| *Rock2 | 6 | Rho-associated, coiled-coil containing PK2 | Hydroxyfasudil |
| Others (idiopathic interstitial pneumonia, community-acquired pneumonia, endotoxemia) | |||
| *Thbs1 | 1 | Thrombospondin 1 | |
| *Irf1 | 2 | Interferon regulatory factor 1 | |
| Neurl3 | 3 | Neuralized homolog 3 | |
| *Tfpi | 4 | Tissue factor pathway inhibitor | Tifacogin |
| Cancer (selected genes) | |||
| *Pdgfrb | 2 | Platelet-derived growth factor receptor-β | Telatinib |
| Tnfsf10 | 3 | TNF superfamily, member 10 | Dulanermin |
| *Cxcl12 | 3 | Chemokine (C-X-C motif) ligand 12 | AMD 3100 and CTCE-9908 |
| Hgf | 3 | Hepatocyte growth factor | AMG 102 |
| Fyn | 4 | FYN oncogene related to SRC, FGR, YES | Dasatinib |
| *Angpt1 | 4 | Angiopoietin 1 | AMG 386 |
| Flt1 | 4 | Fms-related tyrosine kinase 1 | Cediranib, angiozyme |
COPD, chronic obstructive pulmonary disorder; EGF, epidermal growth factor; rPSGL, recombinant P-selectin glycoprotein ligand; ADAM, A disintegrin and metalloproteinase; PPAR, peroxisome proliferator-activated receptor; LDLR, LDL receptor.
*
Genes associated with multiple lung diseases.