Table 1.

Altered expression of Ca²⁺ handling proteins in critical illness myopathy

Protein Measured	Control	CIM
RYR1	100 ± 2.5	135 ± 6.5**
RYR2	100 ± 4.3	171 ± 13**
CaV 1.1	100 ± 5.1	133 ± 9.5**
CaV 1.2	100 ± 5.0	60 ± 7.3**
ORAI, type 1	100 ± 2.5	77 ± 4.9**
NaV 1.4	100 ± 7.6	97 ± 5.2
β-Tubulin	100 ± 5.8	117 ± 6.9

Data are means ± SE; control, n = 19; CIM, n = 16. Values are %average control ± SE. RYR1, ryanodine receptor type 1; RYR2, RYR type 2; Ca_V 1.1; voltage-gated Ca²⁺ channel type 1.1; Ca_V 1.2, Ca_V type 1.2; ORAI type 1, Ca²⁺ release-activated Ca²⁺ protein 1; Na_V 1.4, voltage-gated sodium channel type 1.4.

^**P < 0.01 for CIM relative to control.