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. 2011 Mar 9;300(6):R1333–R1343. doi: 10.1152/ajpregu.00561.2010

Fig. 7.

Fig. 7.

Top: time course of the lumen diameter of the LPCA in absolute units (left) and %changes (right) after a single corneal application of 30 μl of a 1% pilocarpine solution in 10 normotensive Sprague Dawley rats. The maximum response was observed after 9–12 min. *P < 0.05 vs. baseline before drug application (time point 0 min). Middle: Dose response curve for the effect of increasing concentrations of pilocarpine (corneal application, 30 μl) on the lumen diameter of the LPCA in absolute units (left) and percent changes (right). Experiments were performed in 6 normotensive Sprague Dawley rats. The maximum response was obtained at a concentration of 1% pilocarpine. *P < 0.05 vs. baseline before drug application. Bottom: effect of a single corneal application of 1% pilocarpine (30 μl) on lumen diameter of the LPCA in absolute units (left) and %changes (right) after pretreatment with placebo or increasing concentrations of l-NAME. Pretreatment with 4% l-NAME (30 μl) prevented a significant increase in lumen diameter in response to pilocarpine. *P < 0.05 vs. baseline before drug application.