Table 1.
Effect of PVN bicuculline and aCSF on basal values and baroreflex parameters
| Basal Values | MAP, mmHg | HR, bpm | LSNA, % |
|---|---|---|---|
| Control | 103 ± 5 | 367 ± 13 | 100 ± 0 |
| Bicuculline | 115 ± 5* | 430 ± 29* | 222 ± 16* |
| aCSF | 99 ± 4 | 367 ± 19 | 89 ± 12 |
| HR curves | HR Max, bpm | HR Min, bpm | HR Range, bpm | Width, mmHg | BP50, mmHg |
|---|---|---|---|---|---|
| Control | 406 ± 18 | 330 ± 19 | 76 ± 22 | 13.4 ± 2.2 | 123 ± 6 |
| Bicuculline | 475 ± 14* | 344 ± 19* | 132 ± 22* | 11.0 ± 1.9 | 126 ± 3 |
| aCSF | 415 ± 4 | 326 ± 19 | 89 ± 19 | 14.8 ± 1.8 | 121 ± 4 |
| LSNA curves | LSNA Max, % | LSNA Min, % | LSNA Range, % | Width, mmHg | BP50, mmHg |
|---|---|---|---|---|---|
| Control | 149 ± 32 | 1 ± 14 | 148 ± 38 | 12.6 ± 2.6 | 122 ± 7 |
| Bicuculline | 273 ± 48* | 18 ± 17 | 254 ± 44* | 12.7 ± 2.5 | 110 ± 7 |
| aCSF | 148 ± 35 | 10 ± 20 | 138 ± 38 | 12.4 ± 3.0 | 118 ± 6 |
MAP, mean arterial blood pressure; HR, heart rate; LSNA, lumbar sympathetic nerve activity; aCSF, artificial cerebrospinal fluid. Max, baroreflex maximum HR or LSNA; Min, baroreflex minimum HR or LSNA; BP50, see text.
*
P < 0.05, control vs. bicuculline; n = 6 virgin rats.