Table 1.
Basal values of mean arterial pressure, renal hemodynamics, and excretory function in experimental animals
| Group of rats | n | MAP, mmHg | RBF, ml · min−1 · g−1 | GFR, ml · min−1 · g−1 | UF, μl · min−1 · g−1 | UNaV, μmol · min−1 · g−1 | FENa, % |
|---|---|---|---|---|---|---|---|
| Sham | 11 | 113 ± 2 | 6.9 ± 0.3 | 1.5 ± 0.1 | 11.2 ± 1 | 1.2 ± 0.1 | 0.6 ± 0.1 |
| Sham + c-AUCB | 10 | 118 ± 3 | 7.4 ± 0.5 | 1.5 ± 0.1 | 13.1 ± 1.3 | 1.0 ± 0.2 | 0.5 ± 0.1 |
| Sham + HET-0016 | 6 | 111 ± 4 | 6.6 ± 0.7 | 1.5 ± 0.1 | 8.5 ± 1.7 | 0.9 ± 0.3 | 0.3 ± 0.1 |
| 2K1C | 12 | 163 ± 3# | 5.0 ± 0.2# | 1.4 ± 0.1 | 22.0 ± 3.6# | 3.7 ± 0.9# | 1.7 ± 0.3# |
| 2K1C + c-AUCB | 9 | 133 ± 1* | 6.5 ± 0.6* | 1.4 ± 0.1 | 24.7 ± 2.8# | 3.0 ± 0.7# | 1.5 ± 0.3# |
| 2K1C + HET-0016 | 9 | 161 ± 5 | 5.8 ± 0.2* | 1.7 ± 0.1* | 12.9 ± 3.0 | 1.3 ± 0.4* | 0.5 ± 0.2* |
Values are means ± SE. MAP, mean arterial pressure; RBF, renal blood flow; GFR, glomerular filtration rate; UF, urine flow; UNaV, absolute sodium excretion; FENa, fractional sodium excretion; c-AUCB, cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid; 2K1C, 2 kidney, 1 clip. There were significant differences in basal parameters between experimental groups, P < 0.05.
*
Significant difference between treated and nontreated group.
#
Significant difference between sham and 2K1C group.