Table 4.
Adjusted and weighted association between CRP polymorphism rs2808630 and rs3093058 and CKD in African Americans Participants.
| Models | Genotype | OR | 95% CI | ¥ p-value |
|---|---|---|---|---|
| rs2808630 | ||||
| Fully adjusted model | AA | ref** | ||
| AG | 2.94 | 1.61, 5.38 | 0.001* | |
| GG | 2.22 | 0.68, 7.23 | 0.2 | |
| Fully adjusted model plus Log transformed CRP | AA | ref** | ||
| AG | 3.09 | 1.65, 5.80 | 0.001* | |
| GG | 2.41 | 0.79, 7.39 | 0.1 | |
| rs3093058 | ||||
| Fully adjusted model | AA | ref** | ||
| AT | 0.44 | 0.49,1.44 | 0.5 | |
| TT | 0.15 | 0.02, 1.36 | 0.09 | |
| Fully adjusted model plus Log transformed CRP | AA | ref** | ||
| AT | 0.8 | 0.45, 1.41 | 0.4 | |
| TT | 0.15 | 0.02,1.39 | 0.09 | |
¥ Unadjusted for multiple comparisons
*Statistical significance with Bonferroni correction (α/n = 0.05/29) p-value ≤ 0.002
Number of participants by rs2808630 genotype: AA = 1131; AG 419, and GG = 34
**ref. reference group homozygous for the major allele.
Fully adjusted model: adjusted for age, sex, diabetes, hypertension, cardiovascular disease, BMI, smoking and LDL cholesterol