Table 6.
Adjusted and weighted association between CRP polymorphism rs2808630 and albuminuria in African Americans Participants.
| Models | Genotype | OR | 95% CI | ¥ p-value |
|---|---|---|---|---|
| rs2808630 | ||||
| Adjusted for Age and gender (Model 1). | AA | ref* | ||
| AG | 1.68 | 1.27, 2.23 | 0.0009 | |
| GG | 0.99 | 0.47, 2.28 | 0.9 | |
| Adjusted for risk factors | AA | ref* | ||
| AG | 2.95 | 1.54, 5.67 | 0.002 | |
| GG | 1.78 | 0.50, 76.34 | 0.4 | |
| Adjusted for risk factors and Log transformed CRP (Model 2). | AA | ref* | ||
| AG | 3.07 | 1.59, 5.94 | 0.002 | |
| GG | 1.91 | 1.00, 6.54 | 0.3 | |
*ref. reference group homozygous for the major allele.
¥ Unadjusted for multiple comparisons
* Statistical significance with Bonferroni correction (α/n = 0.05/29) p-value ≤ 0.002
Odd ratios are adjusted for:
Model 1: adjusted for age, sex and GFR.
Model 2: age, gender, diabetes, hypertension, cardiovascular disease, BMI, cotinine levels, NSAIDS exposure, LDL cholesterol, GFR and log transformed C reactive protein.