Table 2.
Gene Ontology (GO) term analysis for the C. neoformans FLC response
| GO group | GO subgroup | P-value |
|---|---|---|
| Up-regulated genes | ||
| Oxidation reduction | 5.26e-10 | |
| Small molecule metabolic process | 1.34e-06 | |
| Alcohol metabolic process | 4.74e-07 | |
| Sterol metabolic process | 4.41e-07 | |
| Steroid metabolic process | 7.81e-07 | |
| Phytosteroid metabolic process | 1.47e-09 | |
| Steroid biosynthetic process | 9.08e-07 | |
| Ergosterol biosynthetic process | 3.57e-08 | |
| Transmembrane transport | 0.00076 | |
| Down-regulated genes | ||
| Oxidation reduction | 1.31e-12 | |
| Small molecule metabolic process | 2.50e-11 | |
| Alcohol metabolic process | 0.00037 | |
| Cellular ketone metabolic process | 1.25e-08 | |
| Cellular amino acid and derivative metabolic process | 3.74e-12 | |
| Organic acid metabolic process | 1.63e-08 | |
| Amine metabolic process | 1.47e-13 | |
| Gamma-aminobutyric acid metabolic process | 0.00078 | |
GO term assignment for C. neoformans H99 genes was based on homology to S. cerevisiae genes. P-value represents the probability that a particular GO term is enriched in the microarray gene list. The P-value cut-off was < 0.05.