Table 2.
Virologic Outcomes of EI-AED Compared to NEI-AED Subjects
| EI-AED (N = 19) |
NEI-AED (N = 85) |
OR (95% CI) or Difference ± SE |
Adjusted for Year of and VL at HAART Initiation OR (95% CI) or Difference ± SE |
|
|---|---|---|---|---|
| First HAART/AED Overlap | ||||
| Virologic failure | 10/16 (62.5%) | 20/75 (26.7%) | 4.58 (1.47 - 14.25) P = 0.009 |
4.67 (0.92 - 23.62) P = 0.062 |
| Average VL during period (log10) | 3.3 ± 1.3 (n = 19) | 2.4 ± 1.2 (n = 84) | 0.8 ± 0.3; P = 0.006 |
0.2 ± 0.3; P = 0.376 |
| VL <400 at 6 months | 4/12 (33.3%) | 50/70 (71.4%) | 0.20 (0.05 - 0.74) P = 0.016 |
0.35 (0.06 - 2.07) P = 0.247 |
| VL <400 at 12 months | 4/11 (36.4%) | 42/56 (75.0%) | 0.19 (0.05 - 0.75) P = 0.018 |
0.17 (0.02 - 1.42) p = 0.102 |
| All HAART/AED Overlaps* | ||||
| Virologic failure | 19/30 (63.3%) | 34/122 (27.9%) | 4.29 (1.51 - 12.21) P = 0.006 |
4.19 (1.54 - 11.44) P = 0.005 |
| Average VL during period (log10) | 3.3 ± 1.3 (n = 34) | 2.5 ± 1.3 (n = 142) | 0.9 ± 0.3 P = 0.005 |
0.7 ± 0.3 P = 0.007 |
| VL <400 at 6 months | 8/28 (28.6%) | 84/121 (69.4%) | 0.17 (0.06 - 0.53) P = 0.002 |
0.25 (0.07 - 0.86) P = 0.028 |
| VL <400 at 12 months | 9/23 (39.1%) | 71/96 (74.0%) | 0.21 (0.07 - 0.61) P = 0.004 |
0.22 (0.06 - 0.75) P = 0.016 |
OR (odds ratio): Odds of virologic event for EI-AED cases versus odds for NEI-AED controls; VL, viral load (copies/mL); * Up to three intervals used per subject