Effect of disruption of the transient receptor potential vanilloid-1 (TRPV1) gene by pharmacologic ablation with intrathecal resiniferatoxin, in wild-type (WT) animals (panels A and C) or genetic deletion (Trpv1-Knock Out, KO, panels B and D) on bacterial clearance from the blood (panels A and B) and nitrate/nitrite (NOx) serum levels at 6 and 24 h (panels C and D). Results are shown as means±SEM, number of animals sacrificed at respective time points are shown in parenthesis inside each bar, and * indicates P<0.05 comparing groups with respective controls.