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. Author manuscript; available in PMC: 2012 May 26.
Published in final edited form as: Nature. 2011 May 26;473(7348):470–477. doi: 10.1038/nature10108

Figure 1. Directed electrophilic palladium-catalyzed Ar–F bond-forming reactions.

Figure 1

a, The first palladium-catalyzed fluorination of organic molecules. Phenylpyridine derivatives (1) were fluorinated in the presence of 10 mol% of Pd(OAc)2 and the electrophilic fluorination reagent N-fluoropyridinium tetrafluoroborate (2) under microwave irradiation. b, A palladium-catalyzed directed electrophilic fluorination of C–H bonds of N-benzyltriflamide derivatives (3) with the catalyst Pd(OTf)2·2H2O and the electrophilic fluorination reagent N-fluoro-2,4,6-trimethylpyridinium triflate (4). (Ac: acetyl, Me: methyl, Et: ethyl, Tf: trifluoromethanesulfonyl).