Figure 3. Electrophilic silver-catalyzed Ar–F bond-forming reaction.

a, The first silver-catalyzed Ar–F bond-forming reaction. Aryl stannane derivatives (7) were fluorinated using 5 mol% of Ag₂O as catalyst and the electrophilic fluorination reagent F-TEDA-PF₆ (8). The reaction was applied to late-stage fluorination of complex small molecules, including taxol (9), strychnine (10), and rifamycin (11) derivatives. b, The proposed mechanism of the silver-catalyzed electrophilic fluorination includes three elementary steps: transmetallation, oxidation by an electrophilic fluorination reagent, and C–F reductive elimination. (Bu: butyl).