Table 1.

Association evidence in CARDIoGRAM for previously published loci for coronary disease (previously reported with genome-wide significance (P<5×10⁻⁸).

Band	SNP	Gene(s) in region	n	Risk allele frequency (risk allele)	CARDIoGRAM		reference
					OR (95% CI)	P	OR
1p13.3	rs599839*	SORT1	83,873	0.78 (A)	1.11 (1.08; 1.15)	2.89·10−10	1.29 (1.18; 1.40) 19
1p32.3	rs11206510***	PCSK9	102,352	0.82 (T)	1.08 (1.05; 1.11)	9.10·10−08	1.15 (1.10; 1.21) 8
1q41	rs17465637****	MIA3	25,197	0.74 (C)	1.14 (1.09; 1.20)	1.36·10−08	1.20 (1.12; 1.30) 19
2q33.1	rs6725887*	WDR12	77,954	0.15 (C)	1.14 (1.09; 1.19)	1.12·10−09	1.16 (1.10; 1.22) 8
3q22.3	rs2306374*	MRAS	77,843	0.18 (C)	1.12 (1.07; 1.16)	3.34·10−08	1.15 (1.11; 1.19) 7
6p24.1	rs12526453*	PHACTR1	83,050	0.67 (C)	1.10 (1.06; 1.13)	1.15·10−09	1.13 (1.09; 1.17) 8
6q25.3	rs3798220**	LPA	32,584	0.02 (C)	1.54 (1.36; 1.74)	9.62·10−12	1.92 (1.48; 2.49) 12
9p21.3	rs4977574*	CDKN2A/B, ANRIL	84,256	0.46 (G)	1.29 (1.23; 1.36)	1.35·10−22	1.25 (1.18; 1.31) - 1.37 (1.26; 1.48) 19-6
10q11.21	rs1746048***	CXCL12	136,416	0.87 (C)	1.09 (1.07; 1.13)	2.12·10−10	1.33 (1.20; 1.48) 19
12q24.12	rs3184504*	SH2B3	67,746	0.44 (T)	1.07 (1.04;1.10)	6.35·10−06	1.13 (1.08; 1.18) 20
19p13.2	rs1122608*	LDLR	49,693	0.77 (G)	1.14 (1.09; 1.18)	9.73·10−10	1.14 (1.09; 1.19) 8
21q22.11	rs9982601*	MRPS6	46,230	0.15 (T)	1.18 (1.12; 1.24)	4.22·10−10	1.19 (1.13; 1.27) 8

Data taken ^*from meta-analysis;

^**from replication;

^***from combined analysis,

^****only genotyped data from a subset of studies