Table 2.

Novel loci for coronary disease.

				Meta-analysis		Replication		Combined analysis
Band	SNP	Gene(s) in region	Risk allele frequency (risk allele)	P	n	P	n	OR (95% CI)	P
1p32.2	rs17114036	PPAP2B	0.91 (A)	1.43·10−08	80,870	3.18·10−12	52,356	1.17 (1.13; 1.22)	3.81·10−19
6p21.31	rs17609940	ANKS1A	0.75 (G)	2.21·10−06	83,997	1.18·10−03	53,415	1.07 (1.05; 1.10)	1.36·10−08
6q23.2	rs12190287	TCF21	0.62 (C)	4.64·10−11	78,290	3.25·10−04	52,598	1.08 (1.06; 1.10)	1.07·10−12
7q32.2	rs11556924	ZC3HC1	0.62 (C)	2.22·10−09	80,011	7.37·10−10	54,189	1.09 (1.07; 1.12)	9.18·10−18
9q34.2	rs579459	ABO	0.21 (C)	1.16·10−07	77,138	7.02·10−08	46,840	1.10 (1.07; 1.13)	4.08·10−14
10q24.32	rs12413409	CYP17A1, CNNM2, NT5C2	0.89 (G)	1.47·10−06	80,940	1.38·10−04	48,801	1.12 (1.08; 1.16)	1.03·10−09
11q23.3	rs964184	ZNF259, APOA5-A4-C3-A1	0.13 (G)	8.02·10−10	82,562	2.20·10−09	52,930	1.13 (1.10; 1.16)	1.02·10−17
13q34	rs4773144	COL4A1, COL4A2	0.44 (G)	4.15·10−07	77,113	1.31·10−03	37,618	1.07 (1.05; 1.09)	3.84·10−09
14q32.2	rs2895811	HHIPL1	0.43 (C)	2.67·10−07	63,184	4.59·10−05	51,054	1.07 (1.05; 1.10)	1.14·10−10
15q25.1	rs3825807	ADAMTS7	0.57 (A)	9.63·10−06	80,849	1.39·10−08	48,803	1.08 (1.06; 1.10)	1.07·10−12
17p11.2	rs12936587	RASD1, SMCR3, PEMT	0.56 (G)	4.89·10−07	76,952	1.35·10−04	52,648	1.07 (1.05; 1.09)	4.45·10−10
17p13.3	rs216172	SMG6, SRR	0.37 (C)	6.22·10−07	57,235	2.11·10−04	54,303	1.07 (1.05; 1.09)	1.15·10−09
17q21.32	rs46522	UBE2Z, GIP, ATP5G1, SNF8	0.53 (T)	3.57·10−06	83,867	8.88·10−04	53,766	1.06 (1.04; 1.08)	1.81·10−08