Skip to main content
. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nat Genet. 2011 Mar 6;43(4):333–338. doi: 10.1038/ng.784

Table 3.

Effects of novel CAD loci on traditional risk factors in combined analysis of ARIC and KORA F3/F4 (n = 13,171).

SNP Band Gene(s) in region Phenotype β̂ (95% CI)* P
rs579459 9q34.2 ABO Total cholesterol 1.720 mg/dl (0.554; 2.885) 0.0038
LDL cholesterol 1.538 mg/dl (0.468; 2.608) 0.0049
rs12413409 10q24.32 CYP17A1, CNNM2, NT5C2 Hypertension 0.141 (0.044; 0.238) 0.0043
rs964184** 11q23.3 ZNF259, APOA5-A4-C3-A1 HDL cholesterol −1.926 mg/dl (−2.441; −1.411) 2.28·10−13
Total cholesterol 4.578 mg/dl (3.191; 5.964) 9.84·10−11
LDL cholesterol 1.699 mg/dl (0.417; 2.980) 0.0094

Results from fixed effects meta-analysis based on beta-coefficients and standard errors from linear (total cholesterol, LDL, HDL) and logistic (hypertension) regression analysis of the single studies for which meta-analytic P<0.01.

*

estimated pooled regression coefficients with 95% confidence intervals. LDL = low-density lipoprotein cholesterol, HDL = high-density lipoprotein cholesterol.

**

Previous genome-wide studies have demonstrated strong association of rs964184 with triglycerides 21.