. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Nat Genet. 2011 Mar 6;43(4):333–338. doi: 10.1038/ng.784

Table 3.

Effects of novel CAD loci on traditional risk factors in combined analysis of ARIC and KORA F3/F4 (n = 13,171).

SNP	Band	Gene(s) in region	Phenotype	β̂ (95% CI)^*	P
rs579459	9q34.2	ABO	Total cholesterol	1.720 mg/dl (0.554; 2.885)	0.0038
			LDL cholesterol	1.538 mg/dl (0.468; 2.608)	0.0049
rs12413409	10q24.32	CYP17A1, CNNM2, NT5C2	Hypertension	0.141 (0.044; 0.238)	0.0043
rs964184^**	11q23.3	ZNF259, APOA5-A4-C3-A1	HDL cholesterol	−1.926 mg/dl (−2.441; −1.411)	2.28·10⁻¹³
			Total cholesterol	4.578 mg/dl (3.191; 5.964)	9.84·10⁻¹¹
			LDL cholesterol	1.699 mg/dl (0.417; 2.980)	0.0094

Results from fixed effects meta-analysis based on beta-coefficients and standard errors from linear (total cholesterol, LDL, HDL) and logistic (hypertension) regression analysis of the single studies for which meta-analytic P<0.01.

estimated pooled regression coefficients with 95% confidence intervals. LDL = low-density lipoprotein cholesterol, HDL = high-density lipoprotein cholesterol.

^**

Previous genome-wide studies have demonstrated strong association of rs964184 with triglycerides ²¹.