Table 3.
Effects of novel CAD loci on traditional risk factors in combined analysis of ARIC and KORA F3/F4 (n = 13,171).
SNP | Band | Gene(s) in region | Phenotype | β̂ (95% CI)* | P |
---|---|---|---|---|---|
rs579459 | 9q34.2 | ABO | Total cholesterol | 1.720 mg/dl (0.554; 2.885) | 0.0038 |
LDL cholesterol | 1.538 mg/dl (0.468; 2.608) | 0.0049 | |||
rs12413409 | 10q24.32 | CYP17A1, CNNM2, NT5C2 | Hypertension | 0.141 (0.044; 0.238) | 0.0043 |
rs964184** | 11q23.3 | ZNF259, APOA5-A4-C3-A1 | HDL cholesterol | −1.926 mg/dl (−2.441; −1.411) | 2.28·10−13 |
Total cholesterol | 4.578 mg/dl (3.191; 5.964) | 9.84·10−11 | |||
LDL cholesterol | 1.699 mg/dl (0.417; 2.980) | 0.0094 |
Results from fixed effects meta-analysis based on beta-coefficients and standard errors from linear (total cholesterol, LDL, HDL) and logistic (hypertension) regression analysis of the single studies for which meta-analytic P<0.01.
estimated pooled regression coefficients with 95% confidence intervals. LDL = low-density lipoprotein cholesterol, HDL = high-density lipoprotein cholesterol.
Previous genome-wide studies have demonstrated strong association of rs964184 with triglycerides 21.