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. 2001 Mar 20;98(7):4142–4147. doi: 10.1073/pnas.041490898

Figure 1.

Figure 1

Transmission scheme of TSEs in cynomolgus macaques and C57BL/6 mice. Open frames, natural or accidental disease; hatched frames, experimental disease in primates; stippled frames, experimental disease in mice. IC, intracerebral inoculation; IV, intravenous inoculation; bh, brain homogenate; mth, month. The incubation periods indicated on the arrows each correspond to one inoculated macaque. One macaque was inoculated with British vCJD (25 months), and the other was inoculated with the first French case of vCJD (30 months). The incubation periods of the i.c. titration are as follows: 10−1 dilution: 20 and 21 months; 10−2 dilution: 28 months; 10−3 dilution: 33 months; 10−5 dilution: 38 months (the second macaque inoculated presents slight behavioral changes at 48 months after inoculation).