Table 1.

Incubation periods of C57BL/6 mice inoculated with TSEs

Strain	Donor*	Incubation period,† days
		i.c.		i.c. + i.p.		i.c.	i.c. + i.p.
		Cerebellum	Frontal cortex	Cerebellum	Frontal cortex	Brainstem	Brainstem
Scrapie	Sheep FR	—	—	—	—	773  ± 97§	705  ± 89§
iCJD	Human FR	729  ± 119¶	—	688  ± 114¶	—	—	—
sCJD	Human FR	—	701  ± 98¶	—	668 ± 85¶	—	—
vCJD	Human FR	461  ± 34¶	514  ± 61¶	—	—	—	—
	Human UK1	469  ± 42¶	—	474  ± 44¶	—	—	—
	Human UK2	449  ± 25¶	—	465  ± 69¶	—	—	—
BSE	Cattle UK	—	—	—	—	514  ± 40§	525  ± 47¶
	M. fascicularis	286  ± 15¶	297  ± 15¶	—	277 ± 14§	—	—
	2P M. fascicularis	277  ± 45‡¶	—	—	—	—	—

^*Fr, French case; UK, British case; 2P, second passage in the same host. 

^† Incubation periods are given as mean ± SD for the indicated route and source of inoculum. 

^‡ The i.c. inoculation was performed with 10% brain homogenate; 1% homogenate gave an incubation period of 330 ± 28 days by the i.c. route, 372 ± 35 days by the i.p. route. 

^§n = 15. 

^¶n = 10.