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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: J Immunol. 2010 Jul 16;185(4):2200–2208. doi: 10.4049/jimmunol.1000332

FIGURE 1.

FIGURE 1

Model of liver fibrosis. A, The liver surface contour of thioacetamide/leptin-treated mice at 8 wk is markedly irregular and exhibits diffuse nodularity. B, H&E examination (original magnification×10) of the livers of treated mice reveals a distorted hepatic architectural pattern. Regenerative nodules are seen (asterisk) bounded by fibrous septa (arrows). Picric acid-Sirius red (original magnification×10) staining highlights the collagen network both surrounding and bridging the portal triads. α-SMA staining (original magnification×10) is prominent in the livers of treated mice, suggesting HSC activation. CD45 (original magnification×20) immunohistochemistry confirms the presence of a lymphocytic infiltrate in the livers of treated animals.

HHS Vulnerability Disclosure