FIGURE 4.
LESC are proinflammatory in hepatic fibrosis. A, Freshly isolated LSECs were cultured for 24 h, and inflammatory mediators were measured in cell culture supernatant. p < 0.05 for each comparison. B, NPCs were harvested from the livers of normal and fibrotic mice and cultured for 24 h. Depletion of LSECs from fibrotic NPC concentrates by FACS abrogated their elevated cytokine and chemokine production. Experiments were repeated more than three times and performed in triplicate. p < 0.05 for each inflammatory mediator.