FIGURE 8.

F-LSECs induce potent de novo CTL responses. Naive C57BL/6 mice were either mock immunized or twice immunized using LSEC.OVA₂₅₇ (1 × 10⁶). One week later, in vivo CTL lysis of OVA₂₅₇-presenting cellular targets was measured in the spleen (A) and the liver (B), and splenocyte CTL cultures were assayed for production of IFN-γ (C) and IL-6 (D). Experiments were repeated three times and performed in triplicate using two to four mice per group. *p < 0.05.