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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2011 Mar 15;4(3):362–372. doi: 10.1161/CIRCEP.110.961615

Figure 6.

Figure 6

SERCA2a gene transfer reduces SR Ca2+ leak and normalises the SR Load-Leak relationship in failing cardiomyocytes. A-B. Measurement of tetracaine-dependent SR Ca2+ leak (using method from Shannon et al17). A. Representative examples of Ca2+ transients with paired basal resting levels pre (above) and post (below) 1mM tetracaine (both recorded in 0Na+ 0 Ca2+). B(i). SR Ca2+ leak. B(ii). SR Ca2+ load. B(iii). SR Ca2+ leak per unit load (AMC n=16, HF n=24, HF+S n=13). *p<0.05, ** p<0.01, ***p<0.001.