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. 2001 Mar 20;98(7):4148–4153. doi: 10.1073/pnas.071540198

Figure 1.

Figure 1

Astrocytes exhibit nicotinic cholinergic current responses. (A) A 300-ms application of 1 mM ACh generated a fast desensitizing response (lower trace). This response is absent when the agonist was applied with 10 nM MLA, an αBgt-AChR-specific antagonist (upper trace). (B) Current responses to 1 mM and 100 μM ACh in the presence of atropine from different cells were normalized (peak current = 1) and averaged. Data from 11 cells (1 mM ACh) and 15 cells (100 μM ACh) are shown. ACh responses decay faster at the higher agonist concentration. (C) Current–voltage relationship from a single cell, obtained in the presence of 100 μM ACh, exhibits an inward rectification. Similar results were obtained from 4 cells. All experiments were done in presence of 100 nM atropine to block muscarinic receptors.