Table 2.
Biochemical features and time course of a case of tenofovir-associated Fanconi syndrome.
| Before tenofovir | After 4 years of tenofovir |
One month after tenofovir | Five months after Tenofovir | |
|---|---|---|---|---|
| Serum | ||||
| Creatinine (mg/dL) | 0.96 | 1.5 | 1.3 | 0.9 |
| Glucose (mg/dL) | 97 | 88 | 94 | 79 |
| Uric acid (mg/dL) | 8.4 | 1.2 | 1.8 | 3.4 |
| Potassium (mmol/L | 4.2 | 4.5 | 4.1 | No data |
| Calcium (mg/dL) | 9.1 | 8.5 | 9.2 | 9.2 |
| Phosphorus (mg/dL) | 3.8 | 2 | 3.2 | No data |
| Total proteins (g/dL) | No data | 7.8 | 8.5 | 7.9 |
| PTH (pg/mL) | No data | 128 | 55 | 27 |
| Alkaline phosphatase (UI/L)* | No data | 271 | 242 | 154 |
| Urine and calculated parameters | ||||
| Glycosuria (mg/dL) | Negative | 1000 | No data | Negative |
| Proteinuria (mg/dL) | Negative | 50 | 53 | Negative |
| Tubular reabsorption of phosphate (%) | No data | 34 | 59 | |
| Creatinine clearance (mL/min) | 86 | 26 | 40 | No data |
| Albuminuria/creatinine (mg/g) | 10 | 937 | 303 | No data |
| Light chains κ/λ (mg/dL) | No data | 4.2/4.1 | 2.5/1.7 | 0.6/<0.4 |
| ß-2 microglobulin (ug/24 h) | No data | 4 | 4 | No data |
GGT<10 UI/L at all time points.