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Predictors of significant renal function decline.
| Preexisting renal impairment | |
| Older age | |
| Advanced HIV disease | |
| Vasculometabolic disease | |
| Concomitant use of nephrotoxic drugs or protease inhibitors | |
| Low body weight | |
| ABCC2 gene (encoding the outward tenofovir transporter MRP-2) polymorphisms |
