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. Author manuscript; available in PMC: 2011 Jun 21.
Published in final edited form as: J Cereb Blood Flow Metab. 2008 Jun 11;28(10):1742–1753. doi: 10.1038/jcbfm.2008.56

Figure 4.

Figure 4

Series 2: coregistration of histology, FLASH T2* OC map, and ADC map from a representative animal. (A) The histologic section displaying adjacent fields where neurons were counted and assessed for features of ischemic cell change by an investigator with no prior knowledge of the MRI maps. BZ, border zones; IC, ischemic core; N, normal cortex. Numerical data are presented in Table 2. (B) T2* statistical map overlaid onto the histology section. Colored voxels correspond to a significant T2* signal increase during the inhalation of 100% oxygen; P<0.005. (C) Localization of region of ADC abnormality, shaded white and defined as tissue displaying an ADC value of <83.5% of the average contralateral value (Lo et al, 1997). (D) The area of overlap (outlined in blue) between the ADC abnormality (C) and positive T2* signal change (B). When mapped onto the T2*/ADC maps for each of the five animals, IC always fell within a region showing ADC abnormality and no T2* signal change, BZ fell within the ADC/T2* overlap region or on the boundary on the T2* map between no signal change and a positive signal change, and N fell within the region displaying a normal ADC value and a positive signal change on the T2* map.