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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Expert Rev Gastroenterol Hepatol. 2011 Apr;5(2):201–212. doi: 10.1586/egh.11.6

Figure 3. Cytokeratin 18 and soluble Fas levels as noninvasive markers for nonalcoholic steatohepatitis.

Figure 3

Caspase 3-generated CK18 fragments are produced during hepatocyte apoptosis and can be detected using a monoclonal antibody (M30), both in the liver and in blood. The Fas–Fas ligand complex is a key part of the extrinsic pathway in the hepatocyte apoptotic cascade, and soluble Fas can be measured in the serum using ELISA.

CK18: Cytokeratin 18.