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. Author manuscript; available in PMC: 2011 Jun 21.
Published in final edited form as: Nat Rev Drug Discov. 2011 Apr;10(4):261–275. doi: 10.1038/nrd3428

Figure 4. G-quadruplexes in the promoter of the gene coding for KIT.

Figure 4

a | The minimal promoter structure of the KIT gene showing the spatial relationship between G-quadruplexes KIT1 and KIT2 and a transcription factor Sp1 binding site. Shown in the inset are the sequences of KIT1 and KIT2. b | The two orthogonal views of the averaged nuclear magnetic resonance structure of the KIT1 quadruplex are shown, with the solvent-accessible surface coloured by charge. The arrows indicate the large irregular cleft in the structure, which has not been found in any other G-quadruplex structure determined to date. bp, base pair.