Figure 5.

An odorant receptor mutation is insufficient to induce plasticity. A, We recorded from PNs in glomerulus VM2 in control flies or flies that harbor a mutation in the odorant receptor Or43b. This receptor is normally expressed in olfactory receptor neurons presynaptic to the antennal glomerulus VM2. Antennae were removed acutely and responses were recorded while applying odors to the palps. B, Odor-evoked excitatory local neuron input to VM2 PNs was similar in Or43b mutants versus controls. C, Average membrane potential change in response to four odors (VM2 PNs; as in Fig. 1). There was no significant difference between responses in mutant and control flies (p > 0.05, two-way ANOVA, n = 5 for mutant and control). D, Spontaneous membrane potential fluctuations were also not significantly different (p > 0.05, t test, n = 5 for mutant and control).