. Author manuscript; available in PMC: 2012 May 30.

Published in final edited form as: J Control Release. 2011 Jan 15;152(1):37–48. doi: 10.1016/j.jconrel.2011.01.009

Table 1.

Experimental and calculated dimensions of the SCKs, and quantified DOX loading values.

SCK	12	13	14	15
Polymer precursors	PAA₅₂-b-PS₈₀	PAA₁₂₀-b-PS₁₀₀	PAA₅₂-b-PS₃₀	PAA₁₂₀-b-PS₄₀
D_TEM [nm]	19 ± 2	20 ± 2	11 ± 2	13 ± 2
V_PS [nm³]	3600	4200	700	1200
Aggregation number	270	260	140	180
V_PAA [nm³]	1600	3600	830	2500
T_{shell, calc} [nm]	1.5	2.3	1.5	3.1
V_PAA/V_PS	0.44	0.86	1.2	2.1
(D_h)_Int [nm]	88 ± 6	110 ± 16	81 ± 12	90 ± 12
(D_h)_Vol [nm]	30 ± 3	43 ± 6	20 ± 6	35 ± 2
(D_h)_Num [nm]	24 ± 2	30 ± 3	14 ± 3	18 ± 3
SA_{core/particle} [nm²]	1100	1300	380	530
Total # particles [×10¹⁴, 10 mL solution volume]	4.4	3.0	14	6.1
SA_core/total [×10¹⁷ nm², 10 mL solution volume]	5	4	5	3
D_core,SANS [nm]	17.4	15.3	9.0	8.9
Core size polydispersity	0.13	0.11	0.20	0.33
D_SANS [nm]	24.4	25.1	17.4	17.3
T_{shell, SANS} [nm]	3.5	4.9	4.7	4.2
Related density of shell	4.6	3.0	4.5	2.7
DOX per particle	6400	9700	1500	3800
DOX/V_PAA	4.0	2.7	1.8	1.5

D_TEM = diameter by TEM

V_ps = volume of the PS core

Aggregation number calculated based on diameter by TEM using previously reported equation [61]

V_PAA = volume of the PAA shell, calculated from the TEM core volume to obtain the block copolymer aggregation number, convert to the PAA mass from the total number of AA repeat units, and finally the volume occupied by PAA was determined using a PAA density of 1.05 g/mL

T_{shell, calc} = thickness of the PAA shell in the solid state, estimated from the volume of PAA + volume of PS minus the radius of the PS core

D_h = intensity (Int), volume (Vol), number (Num) average diameters by DLS

SA_{core/particle} = core-shell interfacial area per particle

SA_core/total = core-shell interfacial area for total numbers of particles in 10 mL of aqueous solution

D_core,SANS = core diameter from SANS

D_SANS = particle size from SANS

T_{shell, SANS} = shell thickness from SANS