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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2011 May 3;19(12):3845–3854. doi: 10.1016/j.bmc.2011.04.041

Scheme 2.

Scheme 2

a

aReagents and conditions: (a) Lawesson’s reagent, dry THF, 23 °C, 1 h, 55–57%; (b) methyl α-chloroacetoacetate, absolute ethanol, heat to reflux for 24 h, 51–55%.