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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2011 May 3;19(12):3845–3854. doi: 10.1016/j.bmc.2011.04.041

Scheme 3.

Scheme 3

a

aReagents and conditions: (a) i, NaOH, methanol:H2O (3:5), heat to reflux for 2 h, ii, HCl, 100%; (b) SOCl2, heat to reflux for 2 h, 95%; (c) sodium methanethiolate, dry CH2Cl2, 23 °C, 30 min, 81%.