Table 2.
Adjusted fasting triglyceride (FTG) concentrations by APOE genotype group before and after fenofibrate treatment (160 mg/day).
ε3/ε3 | ε4 Carrier | ε2 Carrier | |
---|---|---|---|
Pre-Fenofibrate | N=666 | N=289 | N=117 |
FTG * (mg/dL) | 109.3 (104, 115) | 120.9 (113, 129)‡b | 130.5 (118, 144)‡c |
Post-Fenofibrate | N=454 | N=203 | N=81 |
FTG*† (mg/dL) | 75.9 (72,80) | 81.9 (76,88) | 85.1 (77, 95) ‡a |
Values are least squares means (95% CIs) adjusted for age, gender, waist circumference, and family relationship
Additionally adjusted for area under the serum fenofibric acid curve
Significantly higher fasting triglyceride concentration when compared to the reference genotype (ε3/ε3). Superscripts a, b and c signify P<0.05, P<0.01and P<0.001, respectively