Table 3.

Area under the curve (AUC) for triglycerides measured at 0, 3.5 and 6 hours after the postprandial lipemia challenge by APOE genotype group before and after 3 weeks fenofibrate treatment (160 mg/day).

	ε3/ε3	ε4 Carrier	ε2 Carrier
Pre-Fenofibrate	N=666	N=289	N=117
AUC*	1077.7 (1022, 1136)	1210.3 (1127, 1299) §e	1340.5 (1211, 1484) §f
AUC*‡	1095.1 (1072, 1119)	1127.7 (1095, 1162)	1161.9 (1112, 1214)§d
Post-Fenofibrate	N=454	N=203	N=81
AUC*†	727.3 (689, 767)	798.3 (742, 858) §d	866.2 (778, 965)§e
AUC*†‡	738.7 (720, 757)	754.6 (730, 779)	793.9 (756, 832) §e

^*Values are least squares means (95% CIs) with arbitrary unit adjusted for age, gender, waist circumference, and family relationship

^†additionally adjusted for area under the serum fenofibric acid curve

^‡additionally adjusted for fasting (0 hour) triglyceride concentration

^§Significantly higher AUC when compared to the reference genoytype (ε3/ε3). Superscripts d, e and f signify d) P<0.05, e) P<0.005, f) P<0.0001