Table 3.
Characteristics of Infants Who Died.*
| Characteristic | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 |
|---|---|---|---|---|---|---|---|
| Intravitreal Bevacizumab for Zone I ROP |
Intravitreal Bevacizumab for Zone I ROP |
Conventional Laser Therapy for Zone I ROP |
Intravitreal Bevacizumab for Zone II ROP |
Intravitreal Bevacizumab for Zone II ROP |
Intravitreal Bevacizumab for Zone II ROP |
Conventional Laser Therapy for Zone II ROP |
|
| Randomization assignment | |||||||
| Birth weight (g) | 595 | 450 | 650 | 470 | 575 | 550 | 665 |
| Gestational age (wk) | 24 | 23 | 28 | 23 | 24 | 24 | 24 |
| Sex | M | F | M | F | F | M | M |
| Mother’s race or ethnic group† | Hispanic | White | Hispanic | White | Black | Black | Hispanic |
| Infants delivered in current pregnancy (no.) | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Intubation before randomization | No | Yes | Yes | Yes | Yes | No | No |
| Postmenstrual age at treatment (wk) | 33.6 | 33.3 | 33.6 | 32.6 | 35.7 | 36.4 | 35.1 |
| Patent ductus arteriosus ligation | No | Yes | No | No | No | Yes | Yes |
| Culture-proven sepsis | Yes | No | Yes | Yes | No | Yes | Yes |
| Surgery for necrotizing enterocolitis | No | No | No | No | Yes | No | Yes |
| Intraventricular hemorrhage‡ | No | No | Yes, grade IV | Yes, grade II | Yes, grade IV | Yes, grade II | Yes, grade IV |
| Periventricular leukomalacia | No | No | No | No | No | No | No |
| Intubated as part of treatment | No | No | No | No | No | No | No |
| Duration of hospitalization from treatment to discharge (days) |
47 | NA | NA | NA | NA | 83 | NA |
| Duration of mechanical ventilation from treatment to discharge (days) |
0 | NA | NA | NA | NA | 1 | NA |
| Duration of oxygen administration from treatment to discharge (days) |
47 | NA | NA | NA | NA | 83 | NA |
| Discharged home while receiving oxygen | Yes | NA | NA | NA | NA | Yes | NA |
| Postmenstrual age at death (wk) | 49.9 | 33.7 | 37.4 | 37.4 | 44.7 | 48.7 | 39.3 |
| Cause of death | Low oxygen | Adherence to do- not-resuscitate order |
Sepsis (coagulase- negative staphy- lococci) |
Respiratory failure | Respiratory failure | Low oxygen | Respiratory failure |
| Location at death | At home (without oxygen monitoring) |
In hospital | In hospital | In hospital | In hospital | At home (without oxygen monitoring) |
In hospital |
*
Data regarding hospital discharge are not given for some infants because they were not discharged. NA denotes not applicable, and ROP retinopathy of prematurity.
†
Mother’s race or ethnic group was self-reported.
‡
Intraventricular hemorrhage can range from grade I to grade IV, with higher grades indicating more severe bleeding.