. Author manuscript; available in PMC: 2012 May 26.

Published in final edited form as: J Med Chem. 2011 May 2;54(10):3524–3548. doi: 10.1021/jm2001053

Table 4.

K_I values for head group modifications.

Compound	Structure	K_I (μM)^a		SphK1 Selectivity^b
Compound	Structure	SphK1	SphK2	SphK1 Selectivity^b
1		0.2	0.5	5
33		1.6	5	6.3
36a		0.13	1.5	24
36b		16	5	0.6
38		0.075	3	80
47		0.099	5.3	110
40		0.13	8	130

K_I = [I]/(K’_M/K_M - 1); K_M of Sphingosine at SphK1 = 10 μM; K_M of Sphingosine at SphK2 = 5 μM

Selectivity = (K_I/K_M)^SphK2/(K_I/K_M)^SphK1