Table 4.
Persistent hydrophilic interaction network in ErbB kinase monomers; bolded entries are salt bridges while non-bolded entries are hydrogen (H-bonds). The entries are aligned so homologous interactions are in line. The conserved active interactions are boxed in brown, while the sequestering interactions are boxed in orange.
| EGFR active | ErbB2 active | ErbB4 active | EGFR inactive | ErbB2 inactive | ErbB3 Inactive | ErbB4 inactive | ||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| aC-helix A-loop interactions | ||||||||
|
| ||||||||
| – – | – – | – – | – – | – – | – – | E739,R841 | ||
|
|
|
|||||||
| E734,K851 | E766,K883 | E739,K856 | – – | – – | – – | – – | ||
|
| ||||||||
| D737,K836 | D769,R868 | – – | – – | – – | – – | D742,R841 | ||
| E738,F832 | – – | E743,F837 | – – | – – | – – | – – | ||
|
|
||||||||
| – – | – – | – – | E738,K836 | – – | – – | E743,R841 | ||
|
| ||||||||
| A-loop C-loop interactions | ||||||||
|
| ||||||||
| – – | – – | – – | – – | G865,V842 | – – | – – | ||
| – – | – – | – – | – – | – – | – – | G838,R817 | ||
|
|
||||||||
| L834,R812 | L866,R844 | L839,R817 | – – | – – | – – | – – | ||
|
| ||||||||
| – – | – – | – – | L834,D813 | – – | – – | – – | ||
|
|
||||||||
| K836,V810 | R868,V842 | R841,V815 | – – | – – | – – | – – | ||
|
| ||||||||
| – – | – – | – – | – – | – – | D838,R814 | – – | ||
| E848,R812 | – – | – – | – – | – – | – – | – – | ||
| – – | – – | – – | K851,R812 | – – | – – | – – | ||
|
| ||||||||
| C-loop C-loop interactions | ||||||||
|
| ||||||||
| – – | H843,D845 | – – | – – | – – | H813,N815 | – – | ||
| – – | – – | – – | R812,D813 | R844,D845 | – – | – – | ||
|
|
||||||||
| D813,R817 | D845,R849 | D818,R822 | – – | – – | – – | – – | ||
|
| ||||||||
| D813,N818 | – – | – – | – – | – – | N815,N820 | – – | ||
| A815,N818 | A847,N850 | A820,N823 | A815,N818 | A847,N850 | A817,N820 | – – | ||
| – – | A848,V851 | – – | – – | – – | – – | – – | ||
|
| ||||||||
| aC-helix interactions | ||||||||
|
| ||||||||
| – – | A763,S760 | – – | – – | – – | – – | – – | ||
| – – | E766,R756 | – – | – – | – – | – – | – – | ||
|
|
||||||||
| E738,K721 | E770,K753 | E743,K726 | – – | – – | – – | – – | ||
|
| ||||||||
| – – | – – | – – | M742,L753 | M774,L785 | – – | M747,L758 | ||
| A743,L679 | – – | A748,Q684 | – – | – – | – – | – – | ||
| – – | – – | – – | – – | – – | – – | A748,R757 | ||
|
| ||||||||
| A-loop interactions | ||||||||
|
| ||||||||
| – – | – – | D836,K726 | – – | D863,K753 | D833,K723 | D836,K726 | ||
|
|
||||||||
| – – | – – | D836,T835 | – – | – – | – – | – – | ||
|
|
||||||||
| L838,R808 | L870,R840 | L843,R813 | – – | – – | – – | – – | ||
|
| ||||||||
| – – | D871,R840 | – – | – – | – – | – – | – – | ||
| – – | – – | – – | – – | – – | D844,K853 | – – | ||
| – – | – – | K848,T873 | – – | – – | – – | – – | ||
| K843,D932 | – – | K848,D937 | – – | – – | – – | – – | ||
| – – | E876,R898 | – – | – – | – – | – – | – – | ||
| – – | – – | E849,K871 | – – | – – | – – | – – | ||
| Y845,Y867 | – – | Y850,F872 | – – | – – | – – | – – | ||
| – – | – – | A852,R870 | – – | – – | – – | – – | ||
| – – | D880,R897 | D853,R870 | E848,R865 | D880,R897 | – – | D853,R870 | ||
| – – | – – | – – | – – | – – | – – | G855,E730 | ||
| – – | – – | – – | – – | K883,E757 | – – | – – | ||
| – – | – – | – – | – – | – – | – – | K856,E844 | ||