Table 3.

Significantly up-regulated pathways in normal HMEC in response to oxidative stress and during cancer malignancy progression. Selection of pathways was based on Fisher Exact p-value. Annotation categories with p-value ≤ 0.05, were considered strongly enriched in up-regulated genes.

KEGG Categories	HMEC GluOx response	HMLER-1 cancer progression	HMLER-5 cancer progression
hsa00190:Oxidative phosphorylation	0.000	0.000	0.000
hsa03010:Ribosome	0.000	0.000	0.000
hsa03050:Proteasome	0.000	0.000	0.000
hsa04110:Cell cycle	0.000	0.000	0.000
hsa00240:Pyrimidine metabolism	0.000	0.000	0.000
hsa00970:Aminoacyl-tRNA biosynthesis	0.000	0.032	0.013
hsa00020:Citrate cycle (TCA cycle)	0.000	0.000	0.000
hsa04120:Ubiquitin mediated proteolysis	0.000	0.000	0.000
hsa00280:Valine, leucine and isoleucine degradation	0.002	*	0.000
hsa00230:Purine metabolism	0.002	0.000	0.000
hsa00130:Ubiquinone biosynthesis	0.013	0.005	0.005
hsa00290:Valine, leucine and isoleucine biosynthesis	0.014	0.000	*
hsa00400:Phenylalanine, tyrosine and tryptophan biosynthesis	0.015	*	0.042
hsa00620:Pyruvate metabolism	0.017	0.028	0.028
hsa03020:RNA polymerase	0.018	0.007	0.006
hsa00062:Fatty acid elongation in mitochondria	0.025	*	*
hsa04130:SNARE interactions in vesicular transport	0.026	0.003	0.007
hsa00071:Fatty acid metabolism	0.031	*	0.046
hsa00630:Glyoxylate and dicarboxylate metabolism	0.033	*	0.016
hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	*	0.016	*
hsa00380:Tryptophan metabolism	*	0.048	0.047
hsa04115:p53 signaling pathway	*	0.018	0.018
hsa00100:Biosynthesis of steroids	*	0.009	0.009
hsa00770:Pantothenate and CoA biosynthesis	*	0.032	0.031
hsa03022:Basal transcription factors	*	0.014	0.036
hsa00030:Pentose phosphate pathway	0.017	0.036	0.036

^*Not statistically significantly represented category based on Fisher Exact p-value.