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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2011 Mar 29;50(11):1565–1574. doi: 10.1016/j.freeradbiomed.2011.03.002

Table 4.

Significantly down-regulated pathways in normal HMEC in response to oxidative stress and during cancer malignancy progression. Selection of pathways was based on Fisher Exact p-value. Annotation categories with p-value ≤ 0.05, were considered strongly enriched in down-regulated genes.

KEGG Categories HMEC GluOx response HMLER-1 cancer progression HMLER-5 cancer progression
hsa04520:Adherens junction 0.000 0.000 0.000
hsa04120:Ubiquitin mediated proteolysis 0.000 0.000 0.000
hsa04510:Focal adhesion 0.001 0.003 0.003
hsa04530:Tight junction 0.003 0.000 0.001
hsa05211:Renal cell carcinoma 0.003 0.033 0.017
hsa04350:TGF-beta signaling pathway 0.004 0.003 0.003
hsa04360:Axon guidance 0.034 0.005 0.003
hsa04010:MAPK signaling pathway 0.036 0.033 0.024
hsa05212:Pancreatic cancer 0.037 0.049 0.039
hsa04210:Apoptosis 0.009 * *
hsa04115:p53 signaling pathway 0.009 * *
hsa04070:Phosphatidylinositol signaling system 0.013 * *
hsa05222:Small cell lung cancer 0.025 * *
hsa05215:Prostate cancer 0.025 * *
hsa04540:Gap junction 0.032 * *
hsa01040:Polyunsaturated fatty acid biosynthesis 0.016 0.032 *
hsa00600:Sphingolipid metabolism * 0.006 0.006
hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis * 0.013 0.013
hsa04330:Notch signaling pathway * 0.013 0.014
hsa04310:Wnt signaling pathway * * 0.024
*

Not statistically significantly represented category based on Fisher Exact p-value.