Table 3. Association of glycemic traits with rs900400 (CCNL1) additive model.

	TT		TC		CC		P value†	Effect (95%CI)	P value‡
	n	Mean (SD)	n	Mean (SD)	n	Mean (SD)
Fasting Glucose (mmol/l) a	1258	5.35 (0.48)	679	5.37 (0.51)	96	5.45 (0.56)	0.18	0.005 (−0.002, 0.012)	0.15
2hour Glucose (mmol/l) a	1258	6.31 (1.48)	679	6.40 (1.40)	96	6.24 (1.32)	0.57	0.004 (−0.010, 0.108)	0.94
Fasting Insulin (pmol/l) a	1009	37.5 (21.5,62.5)	554	37.5 (19.5,61.1)	87	40.9 (21.5,65.3)	0.82	−0.00006 (−0.062, 0.063)	0.99
2 hour Insulin (pmol/l) a	1196	146.5 (82.7,261.1)	644	158.4 (90.3,267.7)	91	150.7 (74.3–286.8)	0.35	0.028 (−0.039, 0.095)	0.41
Insulinogenic Index b, c	941	2.43 (1.23,5.22)	516	2.62 (1.10,5.63)	81	2.58 (1.03,5.31)	0.92	−0.023 (−0.127, 0.112)	0.67
AUC glucose b, d	1257	7.19 (6.41,8.12)	678	7.23 (6.38,8.15)	96	7.07 (6.23,7.91)	0.51	0.00005 (−0.005, 0.005)	0.99
AUC Insulin b d	1249	1.19 (0.70,1.98)	679	1.23 (0.71,2.12)	96	1.27 (0.78,1.97)	0.48	0.018 (−0.043, 0.080)	0.56
HOMA IR b	1254	1.01 (0.39,1.84)	679	0.97 (0.38,1.87)	96	1.29 (0.62,2.08)	0.11	0.073 (−0.026, 0.171)	0.15
HOMA B b	1254	45.76 (18.05,86.62)	679	45.99 (18.04,83.44)	96	59.53 (27.22,85.35)	0.17	0.059 (−0.039, 0.158)	0.24

Data represented as ^amean (SD) and ^bmedian (Inter-quartile range).

^†P values adjusted for gender

^‡P values obtained by regression models adjusted for age, gender, consanguinity and BMI.

^CInsulinogenic index  =  (Insulin ₃₀-fasting Insulin) / ( glucose₃₀-fasting glucose)