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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neurosci Lett. 2011 May 5;498(1):99–103. doi: 10.1016/j.neulet.2011.04.071

Figure 2.

Figure 2

Lethal effects of prolonged exposure to MA, MDMA, and dopamine (DA). (A–B) (A) Survival after prolonged (16 hour) exposure to dopamine. The nsy-1(eg691) allele is semi-dominant for resistance to dopamine-induced lethality. (B) Expression of the nsy-1(eg691) gene restores resistance in the nsy-1(ag3) loss-of-function background, which is hypersensitive to dopamine-induced lethality. (C–D) Survival with long exposure to methamphetamine (C) or MDMA (D). (E) Egg-laying behavior of wild-type N2 versus nsy-1(eg691) on MA. The mutant shows similar drug-induced inhibition of egg-laying as wild-type. (F) Genetic analysis of dopamine-induced lethality. Predicted reduction of function alleles in the PMK-1 p38 MAPK pathway show enhanced sensitivity compared to wild-type or nsy-1(eg691) presumed gain-of-function allele. For tests of statistical significance, see Supplementary Data 1.